مدونة صيدلاوى

New Research Sheds Light on Breast Cancer Prognosis FRIDAY, May 22 -- Two new studies have found that levels of the protein caveolin-1 found in stromal connective tissue near a breast cancer tumor can accurately predict a patient's prognosis and may provide a pathway to future treatments. display_ad(3); window.google_render_ad(); Low levels of caveolin-1, which plays a role in how cells absorb things, in the stromal cells were linked to a poor patient outcome in a study by Dr. Agnieszka K. Witkiewicz, from Thomas Jefferson University in Philadelphia, and colleagues. The findings are published in the June issue of the American Journal of Pathology. The second study, in the same issue of the journal, found that a similar lack of stromal caveolin-1 in mice was associated with more aggressive tumor growth in the rodents, according to Erica K. Sloan, from the Peter MacCallum Cancer Centre in East Melbourne, Australia, and colleagues. The findings led Sloan's research team to hypothe...

New Research Sheds Light on Breast Cancer Prognosis FRIDAY, May 22 -- Two new studies have found that levels of the protein caveolin-1 found in stromal connective tissue near a breast cancer tumor can accurately predict a patient's prognosis and may provide a pathway to future treatments. display_ad(3); window.google_render_ad(); Low levels of caveolin-1, which plays a role in how cells absorb things, in the stromal cells were linked to a poor patient outcome in a study by Dr. Agnieszka K. Witkiewicz, from Thomas Jefferson University in Philadelphia, and colleagues. The findings are published in the June issue of the American Journal of Pathology. The second study, in the same issue of the journal, found that a similar lack of stromal caveolin-1 in mice was associated with more aggressive tumor growth in the rodents, according to Erica K. Sloan, from the Peter MacCallum Cancer Centre in East Melbourne, Australia, and colleagues. The findings led Sloan's research team to hypothe...

Synthetic Vitamin A-Like Molecule Blocks Early MS In tests in mice, Christian Klemann and colleagues at the National Institute of Neuroscience in Tokyo found that the man-made retinoid AM80 prevents early symptoms of the autoimmune disease by blocking the function of Th17 T-cells, a type of immune cell known to play a role in the onset of multiple sclerosis. However, AM80 did not prevent chronic symptoms of the disease, according to the findings published in the June issue of the American Journal of Pathology. display_ad(3); window.google_render_ad(); Multiple sclerosis (MS) attacks the central nervous system. It severs communication between the brain and spinal cord, causing issues from mild numbness in the limbs to paralysis or loss of vision. The disabling disease affects about 2.5 million people globally, according to the National Multiple Sclerosis Society. The treatment -- which unlike some popular MS treatments didn't suppress the immune system and thus subject the patient t...

Synthetic Vitamin A-Like Molecule Blocks Early MS In tests in mice, Christian Klemann and colleagues at the National Institute of Neuroscience in Tokyo found that the man-made retinoid AM80 prevents early symptoms of the autoimmune disease by blocking the function of Th17 T-cells, a type of immune cell known to play a role in the onset of multiple sclerosis. However, AM80 did not prevent chronic symptoms of the disease, according to the findings published in the June issue of the American Journal of Pathology. display_ad(3); window.google_render_ad(); Multiple sclerosis (MS) attacks the central nervous system. It severs communication between the brain and spinal cord, causing issues from mild numbness in the limbs to paralysis or loss of vision. The disabling disease affects about 2.5 million people globally, according to the National Multiple Sclerosis Society. The treatment -- which unlike some popular MS treatments didn't suppress the immune system and thus subject the patient t...

A New Influenza Virus Novel influenza A (H1N1) is a new flu virus of swine origin that was first detected in April, 2009. The virus is infecting people and is spreading from person-to-person, sparking a growing outbreak of illness in the United States. An increasing number of cases are being reported internationally as well. It’s thought that novel influenza A (H1N1) flu spreads in the same way that regular seasonal influenza viruses spread; mainly through the coughs and sneezes of people who are sick with the virus. It’s uncertain at this time how severe this novel H1N1 outbreak will be in terms of illness and death compared with other influenza viruses. Because this is a new virus, most people will not have immunity to it, and illness may be more severe and widespread as a result. In addition, currently there is no vaccine to protect against this novel H1N1 virus. CDC anticipates that there will be more cases, more hospitalizations and more deaths associated with...

A New Influenza Virus Novel influenza A (H1N1) is a new flu virus of swine origin that was first detected in April, 2009. The virus is infecting people and is spreading from person-to-person, sparking a growing outbreak of illness in the United States. An increasing number of cases are being reported internationally as well. It’s thought that novel influenza A (H1N1) flu spreads in the same way that regular seasonal influenza viruses spread; mainly through the coughs and sneezes of people who are sick with the virus. It’s uncertain at this time how severe this novel H1N1 outbreak will be in terms of illness and death compared with other influenza viruses. Because this is a new virus, most people will not have immunity to it, and illness may be more severe and widespread as a result. In addition, currently there is no vaccine to protect against this novel H1N1 virus. CDC anticipates that there will be more cases, more hospitalizations and more deaths associated with...

The New Drug Application (NDA) is the vehicle through which drug sponsors formally propose that the FDA approve a new pharmaceutical for sale and marketing in the United States. The purpose of a NDA is to provide enough information to permit the FDA to reach the following key decisions: Whether the drug is safe and effective in its proposed use(s), and whether the benefits of the drug outweigh the risks. Whether the drug's proposed labeling (package insert) is appropriate, and what it should contain. Whether the methods used in manufacturing the drug and the controls used to maintain the drug's quality are adequate to preserve the drug's identity, strength, quality, and purity. Latest New Drug Applications APF530 (granisetron) Company: A.P. Pharma, Inc. Treatment for: Nausea/Vomiting -- Chemotherapy Induced APF530 is a long-acting formulation of granisetron being developed for the prevention of chemotherapy-induced nausea and vomiting.