مدونة صيدلاوى

Why is it More Difficult to Treat Gram Negative Bacteria Different types of bacteria can be classified into three groups depending upon the thickness of their cell wall. Gram-positive bacteria Gram-negative bacteria Acid fast Gram-positive and gram-negative bacteria can be differentiated easily by gram staining echnique. Treatment It is difficult to treat gram-negative bacteria in comparison to gram-positive bacteria due to following reasons. 1. There is a membrane present around the cell wall of gram-negative bacteria which increases the risk of toxicity to the host but this membrane is absent in gram-positive bacteria. 2. Porin channels are present in gram-negative bacteria which can prevent the entry of harmful chemicals and antibiotics like penicillin. These channels can also expel out antibiotics making much more difficult to treat in comparison to gram-positive bacteria. 3. The risk of resistance against antibiotics is more in Gram-negative