Arythrex
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Composition: Each capsule contains: Celecoxib 100 or 200mg.
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Properties: Arythrex®
(Celecoxib) is a non-steroidal anti-inflammatory drug that exhibits
anti-inflammatory, analgesic and anti-pyretic activities. These effects
are due to inhibition of prostaglandin synthesis, primarily via
inhibition of Cyclooxygenase-2 (COX-2). At therapeutic concentrations
in humans, Arythrex® does not inhibit the cyclooxygenase-1 (COX-1)
isoenzyme.
Pharmacokinetics: - Arythrex® (Celecoxib) is well absorbed from the gastro-intestinal tract and peak plasma concentrations were attained within 3 hours after an oral dose. - Administration of Arythrex® with a high-fat meal resulted in a 1-2 hours delay in the peak plasma concentration levels and a 10-20% increase in the bioavailability. - Arythrex® Capsules can be administered without regard to the timing of meals. - At therapeutic plasma concentrations, Arythrex® is about 97% bound to plasma proteins principally albumin and, to a lesser extent, ?1- acid glycoprotein. - The plasma elimination half-life is about 11 hours. Celecoxib is metabolized in the liver to inactive metabolites principally by the Cytochrome P-450 isoenzyme 2C9. - Approximately 57% and 27% of a single oral dose of Celecoxib is eliminated in the feces and urine respectively. Less than 3% is excreted in the feces and urine unchanged. The primary metabolite is Carboxylic Acid metabolite (73% of the dose). |
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Indications: Arythrex® is indicated for the relief of pain and inflammation in:
- Osteoarthritis - Rheumatoid arthritis - Gouty arthritis - Non-articular disorders such as: Myositis, tendinitis, tenosynovitis and bursitis - Acute pain of any origin - Dysmenorrhea |
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Contra-Indictions: = Known hypersensitivity to Celecoxib.
= Arythrex® should not be given to patients who have experienced allergic-type reactions to sulfonamides. = NSAIDs, including Celecoxib, generally are contra-indicated in patients in whom asthma, urticaria or other sensitivity reactions are precipitated by aspirin or other NSAIDs. |
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Adverse Effects:- Gastro-intestinal disturbances.
- Allergic reactions. - Aggravated hypertension. - Headache. - Dizziness - Rarely adverse renal, ocular and otic effects. |
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Dosage & Administration: The
dosage of Arythrex® should be adjusted according to individual
requirements and response using the lowest possible effective dosage.
- Osteoarthritis: For the symptomatic treatment of osteoarthritis, the usual adult dose is 200mg per day administered as a single dose or as 100mg twice daily. - Rheumatoid arthritis: The usual adult dose is 100-200mg twice daily. - Pain and dysmenorrhea - For the relief of acute pain or dysmenorrhea, the usual initial adult dose is 400mg given as a single dose followed by an additional dose of 200mg, if necessary, on the first day. For continued relief, 200mg may be administered twice daily as needed. |
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How supplied: Strips of 10 Capsules in packs of 1 strip.
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